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Choline

Choline Introduction Choline is an essential nutrient that is naturally present in some foods and available as a dietary supplement. Choline is a source of methyl groups needed for many steps in metabolism. The body needs choline to synthesize phosphatidylcholine and sphingomyelin, two major phospholipids vital for cell membranes. Therefore, all plant and animal cells… Continue reading Choline

Choline’s role in maintaining liver function: new evidence for epigenetic mechanisms

Choline’s role in maintaining liver function: new evidence for epigenetic mechanisms Abstract Purpose of review—Humans eating diets low in choline develop fatty liver and liver damage. Rodents fed choline–methionine-deficient diets not only develop fatty liver, but also progress to develop fibrosis and hepatocarcinoma. This review focuses on the role of choline in liver function, with… Continue reading Choline’s role in maintaining liver function: new evidence for epigenetic mechanisms

Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study

Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study Abstract Background: Glutathione plays crucial roles in the detoxification and antioxidant systems of cells and has been used to treat acute poisoning and chronic liver diseases by intravenous injection. This is a first study examining the therapeutic effects… Continue reading Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study

19 Potential Benefits of Glutathione + Side Effects

19 Potential Benefits of Glutathione + Side Effects What is Glutathione? Why do Some Call it “the Master Antioxidant?” Glutathione (GSH) is your body’s strongest antioxidant. It has an enormous capacity to combat oxidative stress and neutralize harmful free radicals. Chemically speaking, glutathione is a tripeptide made up of 3 amino acids Glutamic acid Cysteine… Continue reading 19 Potential Benefits of Glutathione + Side Effects

The Importance and Regulation of Hepatic Glutathione

The Importance and Regulation of Hepatic Glutathione Glutathione plays a key role in the liver in detoxification reactions and in regulating the thiol-disulfide status of the cell. Glutathione synthesis is regulated mainly by the availability of precursor cysteine and the concentration of glutathione itself which feeds back to regulate its own synthesis. Degradation of hepatic… Continue reading The Importance and Regulation of Hepatic Glutathione

The Effects of Oral L-Arginine and L-Citrulline Supplementation on Blood Pressure.

The Effects of Oral L-Arginine and L-Citrulline Supplementation on Blood Pressure Abstract: Nitric oxide (NO) is a well-known vasodilator produced by the vascular endothelium via the enzyme endothelial nitric oxide synthase (eNOS). The inadequate production of NO has been linked to elevated blood pressure (BP) in both human and animal studies, and might be due… Continue reading The Effects of Oral L-Arginine and L-Citrulline Supplementation on Blood Pressure.

The metabolic basis of arginine nutrition and pharmacotherapy.

The metabolic basis of arginine nutrition and pharmacotherapy As an essential precursor for the synthesis of proteins and other molecules with enormous biological importance (including nitric oxide, urea, ornithine, proline, polyamines, glutamate, creatine, agmatine, and dimethylarginines), arginine displays remarkable metabolic and regulatory versatility. > Read More

Kidney Disease (Nephropathy).

Kidney Disease(Nephropathy) Kidneys are remarkable organs. Inside them are millions oftiny blood vessels that act as filters. Their job is to removewaste products from the blood. Sometimes this filtering system breaks down. Diabetes candamage the kidneys and cause them to fail.Failing kidneys lose their ability to filter out waste products, resulting in kidney disease. >… Continue reading Kidney Disease (Nephropathy).

Acute L-arginine supplementation reduces the O2 cost of moderate-intensity exercise and enhances high-intensity exercise tolerance

Acute L-arginine supplementation reduces the O2 cost of moderate-intensity exercise and enhances high-intensity exercise tolerance J Appl Physiol 109: 1394–1403, 2010. First published August 19, 2010; doi:10.1152/japplphysiol.00503.2010.—It has recently been reported that dietary nitrate (NO3) supplementation, which increases plasma nitrite (NO2) concentration, a biomarker of nitric oxide (NO) availability, improves exercise efficiency and exercise tolerance… Continue reading Acute L-arginine supplementation reduces the O2 cost of moderate-intensity exercise and enhances high-intensity exercise tolerance

Effects of Arginine Supplementation on Athletic Performance Based on Energy Metabolism: A Systematic Review and Meta-Analysis

Effects of Arginine Supplementation on Athletic Performance Based on Energy Metabolism: A Systematic Review and Meta-Analysis Abstract: Nitric oxide related ergogenic aids such as arginine (Arg) have shown to impact positively on sport performance through several physiological and metabolic mechanisms. However, research results have shown to be controversial. The great differences regarding required metabolic pathways… Continue reading Effects of Arginine Supplementation on Athletic Performance Based on Energy Metabolism: A Systematic Review and Meta-Analysis