Resource 1

Thrombosis is the formation of a blood clot, known as a thrombus, within a blood vessel.

It prevents blood from flowing normally through the circulatory system. Nitric Oxide is essential for the prevention of thrombosis.

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Summary

Nitric oxide (NO) is released by the endothelium preventing platelet adhesion to the vessel wall. When released by platelets, NO inhibits further recruitment of platelets to a growing thrombus. Modulation of endogenous NO release may be a mechanism by which the thrombotic response can be regulated as suggested by several clinical diseases associated with impaired bioactive NO. Diseases including atrial fibrillation and coronary atherothrombotic disease have been associated with impaired NO release or decrease in NO bioavailability.

Diseases including atrial fibrillation and coronary atherothrombotic disease have been associated with impaired Nitric Oxide release.

Credit: : Freedman JE, Loscalzo J. Nitric oxide and its relationship to thrombotic disorders. J Thromb Haemost 2003; 1: 1183–8.

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Resource 2

Watch for these signs and symptoms if you think you or someone else may be having a stroke. 

Pay attention to when the signs and symptoms begin. The length of time they have been present can affect your treatment options.

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Signs of Stroke:

· Trouble with speaking and understanding

You may experience confusion. You may slur your words or have difficulty understanding speech.

· Paralysis or numbness of the face, arm or leg

You may develop sudden numbness, weakness or paralysis in your face, arm or leg. This often happens just on one side of your body. Try to raise both your arms over your head at the same time. If one arm begins to fall, you may be having a stroke. Also, one side of your mouth may droop when you try to smile.

· Trouble with seeing in one or both eyes

You may suddenly have blurred or blackened vision in one or both eyes, or you may see double.

· Headache

A sudden, severe headache, which may be accompanied by vomiting, dizziness or altered consciousness, may indicate you’re having a stroke.

· Trouble with walking

You may stumble or experience sudden dizziness, loss of balance or loss of coordination.

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